After vaginal administration, plasma levels are less than 2% of those after a 500 mg oral dose
The aim of the study was to assess the quality of lactation studies with antibiotics using the FDA and International Lactation Consultant Association quality guidelines for lactation studies
Changes during pregnancy and lactation also can trigger pharmacokinetic and pharmacodynamic modifications that alter the effectiveness of antibiotics
Breastfeeding
Metronidazole is considered safe to use when breastfeeding healthy, full-term infants
Vaginal infections like BV normally don't cause any Problems should not be overstated however, as many drugs are considered 'safe' during breastfeeding
Metronidazole—is it safe to use during breastfeeding? Breastfeeding is associated with a decrease in a woman’s risk of breast cancer, ovarian cancer, diabetes mellitus, and hypertensive heart disease 2
Not problems on breastfed infants of treated mothers were found
Metronidazole was discontinued and oral mebendazole 100 mg twice daily was started
A review regarding alcohol consumption during metronidazole treatment reported no in vitro studies, animal models, reports of adverse effects, or clinical studies providing convincing evidence of a disulfiram-like interaction between alcohol and metronidazole (1011)
to the milk may result in central nervous system depression and potentially infant death
Peak concentrations are reached within one to two hours after dosing; however, it may take up to 48 hours before infection-related symptoms start to abate