We present a patient with disseminated granuloma annulare who started treatment with dapsone after several therapeutic failures
Dapsone's mechanism of action in the treatment of granuloma annulare is unclear, but it is known to have profound anti-inflammatory effects on neutrophils
The disease is benign and often self-limited
Oral Dapsone for the Treatment of Generalized Granuloma Annulare Journal of the American Academy of Dermatology Recommend TAKE-HOME MESSAGE
Granuloma Annulare is a long lasting skin rash
Antibiotic combinations such as minocycline plus rifampicin plus ofloxacin
Diagnosis is by clinical evaluation and sometimes biopsy
Although spontaneous remission of granuloma annulare is not uncommon, most cases are chronic and resistant to a variety of therapeutic modalities
The disease is benign and often self-limited
To the Editor: Granuloma annulare is a benign dermatosis that may present in a localized or generalized distribution (generalized granuloma annulare [GGA])
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, brown recluse spider) bites; however, both human and animal data to support its routine use are
The majority of patients tolerated the treatment well
Efficacy of dapsone in disseminated granuloma annulare: A case report and
The localised and disseminated forms are the most common
Authors N Saied, R A Schwartz, S A Estes
Or it may appear on more than one area of the body and become widespread (generalized)
Localized disease is the most common subtype; patients are often women in their 30s
As a resident, I was taught that dapsone was the treatment choice; only every so often would a patient respond, necessitating other approaches
, Irvine California), which was applied twice daily to the lesion
— A 16-year-old girl came to us in April 1978 with a two-month history of a progressive asymptomatic papular eruption on her thighs, buttocks, and hips
The rash occurs most commonly on the hands, feet, wrists and ankles of young adults
The dosing of apremilast was 10 mg the first day, increasing by an increment of 10 mg daily until the maintenance dosage of 30 mg twice daily was
It's generalized or disseminated form is associated with underlying diabetes mellitus and at times it precedes the sign and symptoms of diabetes mellitus
Some patients with sensitivity to other sulphone antibiotics can tolerate dapsone
Reflecting this unmet need, many potential therapeutic approaches have been published in the literature